Professor Eric Diller (MIE) is collaborating with medical researchers to develop dexterous, magnetically controlled microrobots that could perform minimally invasive brain surgery. (Photo: Tyler Irving)
U of T researchers are developing microrobots with unique dexterity capabilities. Controlled by magnetic fields, this technology is a departure from the rigid, wired designs of most micro-surgical tools, and could one day be used to perform minimally invasive brain surgery.
The research team is co-led by Engineering Professor Eric Diller (MIE) and Dr. James Drake of the Department of Surgery and Paediatric Neurosurgeon at The Hospital for Sick Children (SickKids).
“Advancing surgery through an endoscope in the paediatric brain requires miniaturized versatile tools which can be precisely controlled,” explains Drake. “This novel concept of using tiny, magnetized tools, controlled by robotic external magnets shows great promise in addressing this need for both paediatric and adult patients.”
Each year 24,000 malignant brain tumours are detected in the United States. These tumours are the most common form of solid cancer in children, and surgery to remove the tumour is often the first recommended course of treatment. The surgeries can be highly invasive with a long recovery process. In some cases, when surgery via endoscope is possible the tools may not be small or dexterous enough to perform the treatment.
Building on work by Drake and his team at the The Wilfred and Joyce Posluns Centre for Image Guided Innovation & Therapeutic Intervention (PCIGITI), Diller and Drake brainstormed ideas for a research collaboration. Diller pitched the idea of magnetically driven neurosurgical tools, and after securing funding from both the Canadian Institutes of Health Research (CIHR) and the Natural Sciences and Engineering Research Council of Canada (NSERC) , the project took off.
Diller and his team have been developing a prototype with tiny grippers mounted on the end of a flexible wire ‘wrist’ and controlled by external magnetic fields. The tool features magnets on both the gripping forceps and the flexible wrist. As magnetic fields are applied, the tool will either open and close the grippers or move the wrist.
From Lim et al., “Design and Comparison of Magnetically-Actuated Dexterous Forceps Instruments for Neuroendoscopy,” IEEE Trans. Biomed. Eng. © 2021 IEEE
“For these surgical tools we’re working at a very challenging scale of around one- to five-millimetre parts, with some materials that don’t work well with micromachining processes,” says Cameron Forbrigger (MIE PhD Candidate). “As a result, we had to do a lot of the assembly of off-the-shelf magnets, plates, and wires by hand with a laser welding system. If you’re not careful, the titanium wires could disintegrate under the laser beam.”
In tests performed on a rubber model of the brain with a simulated tumour, the gripper was able to successfully enter the ventricles of the brain and remove the tumour, controlled completely by external magnetic fields.
The researchers are now working on a second prototype of the gripping tool that features a simpler design to allow for more control over the forceps. Compared to traditional surgical robot tools, which are about five millimetres across, these prototype magnetic tools are being developed to be half the size, while maintaining the same dexterity.
“Developing new technology for paediatric minimally invasive surgery, in this case neurosurgery, takes a collaborative team of engineers and surgeons. Our team from the Department of Mechanical and Industrial Engineering at U of T and PCIGITI at SickKids has been very successful in this regard,” says Drake.
There are still several steps to be taken before these microrobots are seen in the operating room. The team plans to create more tools, including micro scissors. They also need to determine the best way to generate magnetic fields in the operating room.
“Our next step will be to join our colleagues at SickKids for a simulation in vivo, which will provide the opportunity to see how these microrobots will function in the operating room, and to try different ways of setting up the magnetic coils,” says Diller.
-Published April 30, 2021 by Lynsey Mellon, lynsey@mie.utoronto.ca